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Colorectal Cancer Prognosis Is Not Associated with BRAF and KRAS Mutations-A STROBE Compliant Studyopen access

Authors
Lee, Joon-HyopAhn, JiyoungPark, Won SeoChoe, Eun KyungKim, EunyoungShin, RumiHeo, Seung ChulJung, SoheeKim, KwangsooChai, Young JunChae, Heejoon
Issue Date
Jan-2019
Publisher
MDPI AG
Keywords
colorectal cancer; BRAF; KRAS; overall survival; disease-free survival
Citation
Journal of Clinical Medicine, v.8, no.1
Journal Title
Journal of Clinical Medicine
Volume
8
Number
1
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/3868
DOI
10.3390/jcm8010111
ISSN
2077-0383
Abstract
Background: We investigated the associations between v-Raf murine sarcoma viral oncogene homolog B1 (BRAF(V600E), henceforth BRAF) and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations and colorectal cancer (CRC) prognosis, using The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GSE39582) datasets. Materials and Methods: The effects of BRAF and KRAS mutations on overall survival (OS) and disease-free survival (DFS) of CRC were evaluated. Results: The mutational status of BRAF and KRAS genes was not associated with overall survival (OS) or DFS of the CRC patients drawn from the TCGA database. The 3-year OS and DFS rates of the BRAF mutation (+) vs. mutation (-) groups were 92.6% vs. 90.4% and 79.7% vs. 68.4%, respectively. The 3-year OS and DFS rates of the KRAS mutation (+) vs. mutation (-) groups were 90.4% vs. 90.5% and 65.3% vs. 73.5%, respectively. In stage II patients, however, the 3-year OS rate was lower in the BRAF mutation (+) group than in the mutation (-) group (85.5% vs. 97.7%, p < 0.001). The mutational status of BRAF genes of 497 CRC patients drawn from the GSE39582 database was not associated with OS or DFS. The 3-year OS and DFS rates of BRAF mutation (+) vs. mutation (-) groups were 75.7% vs. 78.9% and 73.6% vs. 71.1%, respectively. However, KRAS mutational status had an effect on 3-year OS rate (71.9% mutation (+) vs. 83% mutation (-), p = 0.05) and DFS rate (66.3% mutation (+) vs. 74.6% mutation (-), p = 0.013). Conclusions: We found no consistent association between the mutational status of BRAF nor KRAS and the OS and DFS of CRC patients from the TCGA and GSE39582 databases. Studies with longer-term records and larger patient numbers may be necessary to expound the influence of BRAF and KRAS mutations on the outcomes of CRC.
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