Defect-Induced Fluorescence of Silica Nanoparticles for Bioimaging Applications
- Authors
- Yoo, Jounghyun; Han, Seulgi; Park, Wonchan; Lee, Taehyung; Park, Yoonsang; Chang, Heemin; Hahn, Sei Kwang; Kwon, Woosung
- Issue Date
- Dec-2018
- Publisher
- AMER CHEMICAL SOC
- Keywords
- silica nanoparticle; defect; dioxasilyrane; silylene; photoluminescence; phosphorescence; bioimaging
- Citation
- ACS APPLIED MATERIALS & INTERFACES, v.10, no.51, pp 44247 - 44256
- Pages
- 10
- Journal Title
- ACS APPLIED MATERIALS & INTERFACES
- Volume
- 10
- Number
- 51
- Start Page
- 44247
- End Page
- 44256
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/4154
- DOI
- 10.1021/acsami.8b16163
- ISSN
- 1944-8244
1944-8252
- Abstract
- With biocompatibility, biodegradability, and high functionality, silica nanoparticles (SNPs) have been widely investigated for various biomedical applications. However, lack of optical fluorescence has limited the application of SNPs as a degradable imaging agent. Here, we hydrothermally synthesized fluorescent SNPs by artificially generating optically active defect centers using tetraethyl orthosilicate and (3-aminopropyl)trimethoxysilane. The synthesized SNPs demonstrated strong blue photoluminescence originating from the dioxasilyrane (=Si(O-2)) and silylene (=Si:) defect centers with the aid of aminopropyl groups. Furthermore, phosphorescence was observed at 459 nm, indicating the presence of silylene in SNPs. Finally, these SNPs have been successfully utilized as a fluorescent probe for bioimaging of normal, cancer, and macrophage cells.
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