Liquid coplanar-gate organic/graphene hybrid electronics for label-free detection of single and double-stranded DNA molecules
- Authors
- Kim, Jin Woo; Jang, Yoon-ha; Ku, Gwang Mo; Kim, Seunghyun; Lee, Eunho; Cho, Kilwon; Lim, Kwang-il; Lee, Wi Hyoung
- Issue Date
- Nov-2018
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Organic/graphene hybrid; Transistor; Coplanar-gate; Biosensor; DNA; Label-free detection
- Citation
- ORGANIC ELECTRONICS, v.62, pp 163 - 167
- Pages
- 5
- Journal Title
- ORGANIC ELECTRONICS
- Volume
- 62
- Start Page
- 163
- End Page
- 167
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/4189
- DOI
- 10.1016/j.orgel.2018.07.032
- ISSN
- 1566-1199
1878-5530
- Abstract
- The label-free detection of DNA with simple device structure and materials helps rapid and effective diagnosis of various diseases. In this study, liquid coplanar-gate graphene field-effect transistors (GFETs) were employed to detect and further distinguish between single-stranded (SS) and double-stranded (DS) DNA molecules. Use of coplanar-gate structure simplified the fabrication steps for GFETs. The liquid coplanar-gate GFETs exhibited higher sensitivity for DNA detection compared to conventional bottom-gate GFETs because they have liquid dielectric layer that was preferred by aqueous DNA. The immobilization of 1-pyrenebutanoic acid succinimidyl ester (PASE) onto graphene surface via pi-pi interaction further enhanced the DNA sensing performances of GFETs. The base parts of the SS DNA molecules can be covalently linked to the succinimidyl ester group in PASE/graphene, thereby leading to n-doping of graphene by action of lone-pair electrons from nitrogen atoms in the base parts. On the other hand, the negatively charged phosphate groups of the DS DNA molecules exposed to graphene surface induced p-doping of graphene. Accordingly, it was possible to distinguish the single and double-stranded DNA molecules by electrical signals. The combined use of liquid coplanar-system and surface modification of graphene with PASE could decrease the detection limit of DNA molecules to 1 nM. The liquid coplanar-gate organic/graphene hybrid electronics platform developed here will allow rapid and convenient label-free detection of single and double stranded DNA molecules.
- Files in This Item
-
Go to Link
- Appears in
Collections - 공과대학 > 화공생명공학부 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.