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Energy landscape of polymorphic amyloid generation of 2-microglobulin revealed by calorimetry
- Authors
- Kinoshita, Misaki; Lin, Yuxi; Dai, Itoh; Okumura, Masaki; Markova, Natalia; Ladbury, John E.; Sterpone, Fabio; Lee, Young-Ho
- Issue Date
- Jul-2018
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.54, no.57, pp 7995 - 7998
- Pages
- 4
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 54
- Number
- 57
- Start Page
- 7995
- End Page
- 7998
- ISSN
- 1359-7345
1364-548X
- Abstract
- Understanding of amyloid aggregation in terms of thermodynamics and kinetics is still limited. We herein examined the mechanism of 2-microglobulin amyloidogenesis using our unique method of isothermal titration calorimetry-based thermodynamic/kinetic measurements, and revealed the energy landscape of polymorphic amyloidogenesis under biological environment-mimicking conditions including shear forces and crowding effects.
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