An isoflavone compound daidzein elicits myoblast differentiation and myotube growth
- Authors
- Lee, Sang-Jin; Tuan Anh Vuong; Go, Ga-Yeon; Song, Yoo-Jin; Lee, Seulah; Lee, Soo-Yeon; Kim, Shin-Woong; Lee, Jaecheol; Kim, Yong Kee; Seo, Dong-Wan; Kim, Ki Hyun; Kang, Jong-Sun; Bae, Gyu-Un
- Issue Date
- Nov-2017
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Akt signaling; Daidzein; Muscle regeneration; Muscular atrophy; Myoblast differentiation; MyoD
- Citation
- JOURNAL OF FUNCTIONAL FOODS, v.38, pp 438 - 446
- Pages
- 9
- Journal Title
- JOURNAL OF FUNCTIONAL FOODS
- Volume
- 38
- Start Page
- 438
- End Page
- 446
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/5058
- DOI
- 10.1016/j.jff.2017.09.016
- ISSN
- 1756-4646
2214-9414
- Abstract
- Preservation of muscle stem cell function is critical for muscle homeostasis and the regenerative capacity of stem cells declines with age, leading to muscle loss. Previously, daidzein, a natural isoflavone from Leguminosae, has been shown to prevent TNF-alpha-induced muscle atrophy. However, the molecular mechanisms of daidzein in these processes are currently unknown. In this study, we demonstrate a positive effect of black soybean extract (BS Ext) and daidzein on myoblast differentiation and myotube growth. Daidzein prevents dexamethasone-induced myotube atrophy through Akt activation. The promyogenic effect of BS Ext and daidzein is mediated through two promyogenic kinases, Akt and p38MAPK that in turn activates a key myogenic transcription factor MyoD. Additionally, BS Ext and daidzein promote myotube growth through AktimTOR/S6K pathway. Finally, daidzein augments MyoD-dependent myogenic conversion of mouse embryonic fibroblasts. Taken together, our data suggest that daidzein promotes myogenic differentiation and myotube hypertrophy through p38 and AktimTOR/S6K pathway. (C) 2017 Elsevier Ltd. All rights reserved.
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