5-Fluorouracil, Leucovorin과 병용 투여된 Oxaliplatin의 Dose Intensity가 재발된 전이성 대장암 치료에 미치는 영향Dose Intensity of Oxaliplatin in 5-Fluorouracil and Leucovorin Regimens in Pretreated Metastatic Colorectal Cancer
- Other Titles
- Dose Intensity of Oxaliplatin in 5-Fluorouracil and Leucovorin Regimens in Pretreated Metastatic Colorectal Cancer
- Authors
- 정경주; 최승기; 오정미
- Issue Date
- Mar-2004
- Publisher
- 한국임상약학회
- Keywords
- Oxaliplatin; metastatic colorectal cancer; dose intensity; objective response; progression free survival
- Citation
- 한국임상약학회지, v.14, no.1, pp 1 - 10
- Pages
- 10
- Journal Title
- 한국임상약학회지
- Volume
- 14
- Number
- 1
- Start Page
- 1
- End Page
- 10
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/60700
- ISSN
- 1226-6051
- Abstract
- Studies of oxaliplatin, 5-fluorouracil and leucovorin in pretreated metastatic colorectal cancer showed that oxaliplatin dose intensity is important prognostic factor for objective response rates and progression-free-survival (PFS). To evaluate response rates, PFS and toxicity according to oxaliplatin dose intensity, we retrospectively analyzed data from patients with metastatic colorectal cancer received oxaliplatin, 5-fluorouracil, leucovorin regimens. Sixty-three patients were reviewed in this study, 42 patients received low dose intensity oxaliplatin (LDI: 85 mg/m2/2wks) and 21 patients high dose intensity oxaliplatin (HDI: >85 mg/m2/2wks). Objective responses occurred in 10 (47.7%) HDI patients and 9 (21.4%) LDI patients (p = 0.014). Median PFS was 24.7 weeks in HDI group, with 45.1% of HDI patients progression free at 6 months, and 20.5 weeks in LDI group, with 33.5% of LDI patients progression free at 6 months (p = 0.344). Increased oxaliplatin dose intensity was not associated with neutropenia, thrombocytopenia, neuropathy, nausea and vomiting. This study showed that oxaliplatin dose intensification significantly improves objective response rate in pretreated metastatic colorectal cancer without increasing severe toxicity.
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