Circulating folate levels and colorectal adenoma: a case-control study and a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Park, Yeong Mi | - |
dc.contributor.author | Youn, Jiyoung | - |
dc.contributor.author | Cho, Chang Ho | - |
dc.contributor.author | Kim, Sung Hi | - |
dc.contributor.author | Lee, Jung Eun | - |
dc.date.available | 2021-02-22T11:11:44Z | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 1976-1457 | - |
dc.identifier.issn | 2005-6168 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/8118 | - |
dc.description.abstract | BACKGROUND/OBJECTIVES: The relationship between folate and colorectal neoplasia remains controversial. We examined the association between serum folate concentrations and colorectal adenomas in a case-control study of Korean adults and conducted a meta-analysis. SUBJECTS/METHODS: Our case-control study included 113 pairs of case and control who underwent colonoscopy and provided blood samples. We used multivariable conditional logistic regression models to obtain the odds ratios and 95% confidence interval (Cls). For meta-analysis, we identified the relevant studies by searching the PubMed database up to February 2017, included our case-control study and combined the study-specific relative risks (RRs) using a random-effects model. RESULTS: In this case-control study, we included 58 men and 55 women with colorectal adenomas and sex and fasting status matched the controls. We did not find any significant association between the serum folate levels and colorectal adenomas in either men or women. For meta-analysis, a total of eleven studies were included in our analysis and classified into two groups; polyp clearance group (PC) for the studies that included participants who underwent endoscopies and had their polyps removed at baseline; and no polyp clearance group (NPC) for the studies that included participants whose histories of endoscopies were unknown or who underwent their first endoscopies. Four PC (1,311 cases and 1,672 non-cases) and eight NPC studies (3,501 cases and 11,347 non-cases) were included. The combined RRs (95% Cls) comparing the bottom with the top categories of circulating folate levels were 1.07 (0.97-1.18) for the NPC group but 1.45 (1.16-1.74) for the PC group. CONCLUSIONS: Low circulating folate levels were associated with new adenoma formation. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN NUTRITION SOC | - |
dc.title | Circulating folate levels and colorectal adenoma: a case-control study and a meta-analysis | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.4162/nrp.2017.11.5.419 | - |
dc.identifier.scopusid | 2-s2.0-85030862047 | - |
dc.identifier.wosid | 000413391600009 | - |
dc.identifier.bibliographicCitation | NUTRITION RESEARCH AND PRACTICE, v.11, no.5, pp 419 - 429 | - |
dc.citation.title | NUTRITION RESEARCH AND PRACTICE | - |
dc.citation.volume | 11 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 419 | - |
dc.citation.endPage | 429 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002270564 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | RANDOMIZED CLINICAL-TRIAL | - |
dc.subject.keywordPlus | MTHFR C677T POLYMORPHISM | - |
dc.subject.keywordPlus | ONE-CARBON METABOLISM | - |
dc.subject.keywordPlus | DNA EXCISION-REPAIR | - |
dc.subject.keywordPlus | PLASMA FOLATE | - |
dc.subject.keywordPlus | CANCER RISK | - |
dc.subject.keywordPlus | FOLIC-ACID | - |
dc.subject.keywordPlus | METHYLENETETRAHYDROFOLATE-REDUCTASE | - |
dc.subject.keywordPlus | SERUM FOLATE | - |
dc.subject.keywordPlus | URACIL MISINCORPORATION | - |
dc.subject.keywordAuthor | Folate | - |
dc.subject.keywordAuthor | colorectal adenoma | - |
dc.subject.keywordAuthor | meta-analysis | - |
dc.identifier.url | https://e-nrp.org/DOIx.php?id=10.4162/nrp.2017.11.5.419 | - |
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