Diarylheptanoids suppress proliferation of pancreatic cancer PANC-1 cells through modulating shh-Gli-FoxM1 pathway
- Authors
- Dong, Guang-zhi; Jeong, Ji Hye; Lee, Yu-ih; Lee, So Yoon; Zhao, Hui-Yuan; Jeon, Raok; Lee, Hwa Jin; Ryu, Jae-Ha
- Issue Date
- Apr-2017
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- Diarylheptanoids; Alpinia officinarum; Alnus japonica; FoxM1; Gli; PANC-1 pancreatic cancer cell; (E)-7-(4-hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one; Platyphyllenone
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.40, no.4, pp 509 - 517
- Pages
- 9
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 40
- Number
- 4
- Start Page
- 509
- End Page
- 517
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/8583
- DOI
- 10.1007/s12272-017-0905-2
- ISSN
- 0253-6269
1976-3786
- Abstract
- Pancreatic cancer is one of the leading causes of cancer, and it has the lowest 5-year survival rates. It is necessary to develop more potent anti-pancreatic cancer drugs to overcome the fast metastasis and resistance to surgery, radiotherapy, chemotherapy, and combinations of these. We have identified several diarylheptanoids as anti-pancreatic cancer agents from Alpinia officinarum (lesser galangal) and Alnus japonica. These diarylheptanoids suppressed cell proliferation and induced the cell cycle arrest of pancreatic cancer cells (PANC-1). Among them, the most potent compounds 1 and 7 inhibited the shh-Gli-FoxM1 pathway and their target gene expression in PANC-1 cells. Furthermore, they suppressed the expression of the cell cycle associated genes that were rescued by the overexpression of exogenous FoxM1. Taken together, (E)-7-(4-hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one (1) from Alpinia officinarum (lesser galangal) and platyphyllenone (7) from Alnus japonica inhibit PANC-1 cell proliferation by suppressing the shh-Gli-FoxM1 pathway, and they can be potential candidates for anti-pancreatic cancer drug development.
- Files in This Item
-
Go to Link
- Appears in
Collections - 약학대학 > 약학부 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.