Six-week open-label trial of topiramate to treat disruptive behaviors in children and adolescents with or without mental retardation
DC Field | Value | Language |
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dc.contributor.author | Shin W.C. | - |
dc.contributor.author | Song D.H. | - |
dc.contributor.author | Ha E.H. | - |
dc.contributor.author | Shin Y.J. | - |
dc.date.available | 2021-02-22T11:16:55Z | - |
dc.date.issued | 2006-09 | - |
dc.identifier.issn | 1738-3684 | - |
dc.identifier.issn | 1976-3026 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/8778 | - |
dc.description.abstract | Objective: Anticonvulsants are known to be effective to manage affective instability and aggressive behavior by reducing neuronal excitability. This study examined the efficacy and safety of topiramate, a novel anticonvulsant, on disruptive behavioral problems in children and adolescents, with or without mental retardation (MR), and the differences of short-term efficacy and safety according to the IQ levels. Methods and Materials: Fifty-four children and adolescents with disruptive behavioral problems were enrolled in a 6-week, open-label study. All subjects were divided into 3 groups (subjects without MR, Non-MR; subjects with mild MR, Mild MR; and subjects with moderate to severe MR, Mod-Severe MR) based on their intellectual ability, and treated with topiramate. Outcome measures included the Aberrant Behavior Checklist Hyperactivity (ABC-H) and Irritability (ABC-I) subscales and the Clinical Global Impression Severity (CGI-S) scale. Results: Significant reduction of CGI-S, ABC-H, and ABC-I scores were noted in all three groups in the following order: Non-MR, Mild MR, and Mod-Severe MR. Parethesia, anorexia, somnolence, nocturnal enuresis, and urinary frequency were relatively common adverse event. However, no serious adverse events were reported. Conclusions: Topiramate was effective and well tolerated for managing disruptive behavioral problems and emotional instability in children and adolescents. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한신경정신의학회 | - |
dc.title | Six-week open-label trial of topiramate to treat disruptive behaviors in children and adolescents with or without mental retardation | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.scopusid | 2-s2.0-33748928814 | - |
dc.identifier.bibliographicCitation | Psychiatry Investigation, v.3, no.2, pp 73 - 80 | - |
dc.citation.title | Psychiatry Investigation | - |
dc.citation.volume | 3 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 73 | - |
dc.citation.endPage | 80 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | anticonvulsive agent | - |
dc.subject.keywordPlus | topiramate | - |
dc.subject.keywordPlus | adolescent | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | anorexia | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | clinical trial | - |
dc.subject.keywordPlus | controlled clinical trial | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | disruptive behavior | - |
dc.subject.keywordPlus | drug efficacy | - |
dc.subject.keywordPlus | drug safety | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | intelligence quotient | - |
dc.subject.keywordPlus | major clinical study | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | mental deficiency | - |
dc.subject.keywordPlus | nocturnal enuresis | - |
dc.subject.keywordPlus | paresthesia | - |
dc.subject.keywordPlus | randomized controlled trial | - |
dc.subject.keywordPlus | school child | - |
dc.subject.keywordPlus | side effect | - |
dc.subject.keywordPlus | somnolence | - |
dc.subject.keywordPlus | urinary frequency | - |
dc.subject.keywordAuthor | Disruptive behavior | - |
dc.subject.keywordAuthor | Mental retardation | - |
dc.subject.keywordAuthor | Topiramate | - |
dc.subject.keywordAuthor | Youth | - |
dc.identifier.url | http://scholar.dkyobobook.co.kr/searchDetail.laf?barcode=4050026368965 | - |
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