Tumor necrosis factor-alpha and interleukin-1 beta increases CTRP1 expression in adipose tissue
- Authors
- Kim, Kun-yong; Kim, Hwa Young; Kim, Jae Hyeong; Lee, Chul-Ho; Kim, Do-Hyung; Lee, Young Ho; Han, Seung Hyun; Lim, Jong-Seok; Cho, Dae Ho; Lee, Myeong-Sok; Yoon, Sukjoon; Kim, Keun Il; Yoon, Do-Young; Yang, Young
- Issue Date
- Jul-2006
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- adipokine; proinflammatory cytokines; CTRP
- Citation
- FEBS LETTERS, v.580, no.16, pp 3953 - 3960
- Pages
- 8
- Journal Title
- FEBS LETTERS
- Volume
- 580
- Number
- 16
- Start Page
- 3953
- End Page
- 3960
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/8806
- DOI
- 10.1016/j.febslet.2006.06.034
- ISSN
- 0014-5793
1873-3468
- Abstract
- CTRP1, a member of the CTRP superfamily, consists of an N-terminal signal peptide sequence followed by a variable region, a collagen repeat domain, and a C-terminal globular domain. CTRP1 is expressed at high levels in adipose tissues of LPS-stimulated Sprague-Dawley rats. The LPS-induced increase in CTRP1 gene expression was found to be mediated by TNF-alpha and IL-1 beta. Also, a high level of expression of CTRP1 mRNA was observed in adipose tissues of Zucker diabetic fatty (falfa) rats, compared to Sprague-Dawley rats in the absence of LPS stimulation. These findings indicate that CTRP1 expression may be associated with a low-grade chronic inflammation status in adipose tissues. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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