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Trimethyl Lock Quinone-Functionalized Coumarin for Real-time Monitoring of NQO1 Activity in the Live Cells
- Authors
- Park, Sun Young; Yoon, Shin A; Lee, Min Hee
- Issue Date
- Jan-2021
- Publisher
- 대한화학회
- Keywords
- Fluorescence imaging probe; NQO1 enzyme; Real-time monitoring; Trimethyl lock quinone-functionalized coumarin
- Citation
- Bulletin of the Korean Chemical Society, v.42, no.1, pp 119 - 123
- Pages
- 5
- Journal Title
- Bulletin of the Korean Chemical Society
- Volume
- 42
- Number
- 1
- Start Page
- 119
- End Page
- 123
- ISSN
- 0253-2964
1229-5949
- Abstract
- We developed trimethyl lock quinone-functionalized coumarin (probe 1) as a small fluorescent probe for the imaging of NQO1 activity in the live cells. NQO1 is highly expressed in most cancer cells and it is considered as a potential biomarker of NQO1-related cancer. Probe 1 showed the high selectivity and rapid fluorescence response to the NQO1 activity. In addition, the probe is biocompatible and easily penetrates living cells. It was found that probe 1 provided relatively strong fluorescence in NQO1-positive A549 cells, unlike NQO1-negative NIH-3T3 and MDA-MB-231 cells. Therefore, we demonstrated that probe 1 can detect NQO1 activity in real time in living cells and it can also distinguish different levels of NQO1 activity in various pathological cells.
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