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Essential role of interferon regulatory factor 4 (IRF4) in immune cell development

Authors
Nam, SorimLim, Jong-Seok
Issue Date
Nov-2016
Publisher
PHARMACEUTICAL SOC KOREA
Keywords
Interferon regulatory factor 4 (IRF4); Lymphoid cells; Myeloid cells; Dendritic cells (DCs); Macrophages; Myeloid-derived suppressor cells (MDSCs)
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.39, no.11, pp.1548 - 1555
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
Volume
39
Number
11
Start Page
1548
End Page
1555
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/9363
DOI
10.1007/s12272-016-0854-1
ISSN
0253-6269
Abstract
The family of interferon regulatory factors, which includes nine mammalian members ( IRF1-IRF9), acts as transcription factors for interferons and thus exerts regulatory functions in the immune system and in oncogenesis. Among these members, IRF4 expression is restricted to immune cells such as T and B lymphocytes, macrophages, and dendritic cells where it is a key factor in the regulation of differentiation and is required during the immune response for lymphocyte activation and the generation of immunoglobulin-secreting plasma cells. Consequently, dysregulation of IRF4 is associated with many lymphoid malignancies. Recent studies have demonstrated that depending on the context and stage of hematopoietic cell differentiation in which its expression is dysregulated, IRF4 may act as either an oncogene or a tumor-suppressor-like factor. In addition, it has been shown that IRF4 plays a pivotal role in the development and function of several autoimmune-associated cells. Various genetic and functional studies have also pointed to IRF4 as a master regulator for autoimmunity. In this review, the roles of IRF4 in the immune response are briefly summarized and discussed, with particular focus on its essential and distinct functions in immune cell development.
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