Circulating levels of vitamin D and colorectal adenoma: A case-control study and a meta-analysis
- Authors
- Choi, Yoon Ji; Kim, Young Ha; Cho, Chang Ho; Kim, Sung Hi; Lee, Jung Eun
- Issue Date
- Aug-2015
- Publisher
- BAISHIDENG PUBLISHING GROUP INC
- Keywords
- 25-hydroxyvitamin D levels; Colorectal adenoma; Cancer prevention
- Citation
- WORLD JOURNAL OF GASTROENTEROLOGY, v.21, no.29, pp 8868 - 8877
- Pages
- 10
- Journal Title
- WORLD JOURNAL OF GASTROENTEROLOGY
- Volume
- 21
- Number
- 29
- Start Page
- 8868
- End Page
- 8877
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10469
- DOI
- 10.3748/wjg.v21.i29.8868
- ISSN
- 1007-9327
2219-2840
- Abstract
- AIM: To examine the association between circulating 25-hydroxyvitamin D [25(OH) D] levels and colorectal adenoma in a case-control study and a meta-analysis. METHODS: We conducted a matched case-control study (112 cases and 112 matched controls) and combined 15 studies, including our study, in a metaanalysis. The study-specific odds ratios (ORs) and 95% confidence intervals (CIs) were pooled using a randomeffects model. In total, 5454 colorectal adenomas and 6656 controls were included in the meta-analysis. RESULTS: In a meta-analysis including 14 previous studies and our study, we observed a significant inverse association between circulating 25(OH) D levels and colorectal adenoma (OR = 0.68; 95% CI: 0.54-0.82) when comparing the highest category with the lowest category. Stratification by adenoma location (proximal or distal adenoma) showed similar estimates. When we stratified by study region, the ORs (95% CIs) were 0.70 (0.52-0.88) in the US and 0.66 (0.34-0.97) in Asia. CONCLUSION: These data suggest an inverse association between circulating 25(OH) D levels and colorectal adenoma in both Western and Asian populations.
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