Suppression of 7,12-dimethylbenz(a) anthracene-induced mammary tumorigenesis by glyceollins
DC Field | Value | Language |
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dc.contributor.author | Kim, Bo Ram | - |
dc.contributor.author | Seo, Ji-Yeon | - |
dc.contributor.author | Sung, Mi-Kyung | - |
dc.contributor.author | Park, Jung Han Yoon | - |
dc.contributor.author | Suh, Hwa-Jin | - |
dc.contributor.author | Liu, Kwang Hyeon | - |
dc.contributor.author | Kim, Jong-Sang | - |
dc.date.available | 2021-02-22T11:35:37Z | - |
dc.date.issued | 2015-05 | - |
dc.identifier.issn | 1613-4125 | - |
dc.identifier.issn | 1613-4133 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10534 | - |
dc.description.abstract | Scope: Our previous study showed that glyceollins induced phase 2 detoxifying and antioxidant enzymes. As chemical carcinogens can be detoxified by metabolic activity of phase 2 enzymes, subsequently decreasing their tumorigenic potential, we investigated whether 7,12dimethylbenz(a) anthracene (DMBA)-inducedmammary tumorigenesis could be attenuated by treatment with glyceollins in a mouse model. Methods and results: Pretreatment with glyceollins (5 mg/kg body weight) caused a significant reduction in tumor formation and an increase in survival rate. The protective effect of glyceollins against DMBA-induced tumorigenesis was found to be mainly associated with their potential to induce phase 2/antioxidant enzymes that are, in turn, regulated by the nuclear factor E2-related factor 2 signaling pathway, and to a less extent to suppress phase 1 enzymes. As glyceollins increased the number of terminal end buds, a tumor-prone mammary tissue type in mice, it is unlikely that they exert their antitumorigenic action through their estrogenic activity. Conclusion: Glyceollins were found to have a protective effect in a chemically induced mammary tumor model. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | Suppression of 7,12-dimethylbenz(a) anthracene-induced mammary tumorigenesis by glyceollins | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1002/mnfr.201400726 | - |
dc.identifier.scopusid | 2-s2.0-84928676423 | - |
dc.identifier.wosid | 000354240800007 | - |
dc.identifier.bibliographicCitation | MOLECULAR NUTRITION & FOOD RESEARCH, v.59, no.5, pp 907 - 917 | - |
dc.citation.title | MOLECULAR NUTRITION & FOOD RESEARCH | - |
dc.citation.volume | 59 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 907 | - |
dc.citation.endPage | 917 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | NRF2-MEDIATED INDUCTION | - |
dc.subject.keywordPlus | METABOLIC-ACTIVATION | - |
dc.subject.keywordPlus | DETOXIFYING ENZYMES | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | ESTRADIOL | - |
dc.subject.keywordPlus | NRF2 | - |
dc.subject.keywordAuthor | DMBA | - |
dc.subject.keywordAuthor | Glyceollins | - |
dc.subject.keywordAuthor | Mammary tumor | - |
dc.subject.keywordAuthor | Nrf2 | - |
dc.subject.keywordAuthor | Phase 2 detoxifying enzymes | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1002/mnfr.201400726 | - |
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