한방 발효주 주박 추출물의 미백 및 피부 주름 개선 효과Skin whitening and anti-wrinkle effects of extract from Jubak of oriental herbal liquor
- Other Titles
- Skin whitening and anti-wrinkle effects of extract from Jubak of oriental herbal liquor
- Authors
- 이수민; 이상진; 권이영; 백상훈; 김종식; 손호용; 신우창
- Issue Date
- Nov-2014
- Publisher
- Korean Society of Food Science and Nutrition
- Keywords
- Anti-melanogenesis; Anti-wrinkle; Antioxidant; Jubak; Oriental herbal liquor
- Citation
- Journal of the Korean Society of Food Science and Nutrition, v.43, no.11, pp 1695 - 1700
- Pages
- 6
- Journal Title
- Journal of the Korean Society of Food Science and Nutrition
- Volume
- 43
- Number
- 11
- Start Page
- 1695
- End Page
- 1700
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10769
- DOI
- 10.3746/jkfn.2014.43.11.1695
- ISSN
- 1226-3311
2288-5978
- Abstract
- Oriental herbal liquor (Yakju) is a type of Korean traditional alcoholic beverage that uses Nuruk and oriental herbs for fermentation. The purpose of this study was to develop cosmetic ingredients using Jubak, which is a by-product of alcoholic fermentation of oriental herbal liquor. To investigate antioxidant, whitening, and anti-aging effects of Jubak, we prepared extract of Jubak and its solvent fractions. Ethyl acetate fraction (KSD E4-3) showed the most prominent free radical [1,1-diphenyl-2-picrylhydrazyl (DPPH)] scavenging activity (SC50: 0.75 mg/mL). KSD E4-3 significantly inhibited in vitro mushroom tyrosinase activity (IC50: 0.82 mg/mL) and reduced the melanin contents in mouse melanoma melanocyte, B16F10 cells. KSD E4-3 down-regulated protein expression of tyrosinase related proteins (TRP)-1, -2, which play key roles in melanogenesis. For anti-aging effects, inhibition of matrix metalloproteinase (MMPs) expression was evaluated using human keratinocyte, HaCaT cells. Treatment of HaCaT cells with KSD E4-3 reduced expression of MMP-1, -2, -9 and inhibited proteolytic activities of MMP-2, -9. These results suggest that KSD E4-3 induces down-regulation of cellular melanogenesis and protects against photoaging induced by UVB-induced damage. Thus KSD E4-3 could potentially be a valuable cosmetic ingredient. © 2014, Korean Society of Food Science and Nutrition. All rights received.
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