Cyanidin-3-O-Sambubioside from Acanthopanax sessiliflorus Fruit Inhibits Metastasis by Downregulating MMP-9 in Breast Cancer Cells MDA-MB-231
- Authors
- Lee, Sang-Jin; Hong, Sungyoul; Yoo, Sang-Ho; Kim, Gye-Won
- Issue Date
- Nov-2013
- Publisher
- GEORG THIEME VERLAG KG
- Keywords
- angiogenesis; cancer metastasis; cyanidin-3-O-sambubioside; fruit of Acanthopanax sessiliflorus; Araliaceae; invasion; MMP-9
- Citation
- PLANTA MEDICA, v.79, no.17, pp 1636 - 1640
- Pages
- 5
- Journal Title
- PLANTA MEDICA
- Volume
- 79
- Number
- 17
- Start Page
- 1636
- End Page
- 1640
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/11196
- DOI
- 10.1055/s-0033-1350954
- ISSN
- 0032-0943
1439-0221
- Abstract
- Anthocyanins play an important role in physiological functions related to human health. This study aimed to investigate the inhibitory effect of cyanidin-3-O-sambubioside isolated from Acanthopanax sessiliflorus fruit on cancer cell metastasis. The inhibitory effect of cyanidin-3-O-sambubioside on angiogenesis was assessed by chorioallantoic membrane and tube formation assays. Cyanidin-3-O-sambubioside interrupted the formation of neovasculature and tube-like structures in a dose-dependent manner. It inhibited the wound healing migration and invasion of MDA-MB-231 cells through reconstituted extracellular matrix (Matrigel). Gelatin zymography revealed that cyanidin-3-O-sambubioside significantly decreased the secretion of matrix metalloproteinase-9 and inhibited matrix metalloproteinase-9 expression. In additional, cyanidin-3-O-sambubioside exerted an inhibitory effect on Akt phosphorylation. These results suggest that cyanidin-3-O-sambubioside inhibits metastasis processes, such as angiogenesis and invasion, in breast cancer cells through regulation of matrix metalloproteinase-9 activity.
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