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Autophagy induction promotes renal cyst growth in polycystic kidney disease

Authors
Lee, Eun JiKo, Je YeongOh, SuminJun, JaeheeMun, HyowonLim, Chae JiSeo, SeungwoonKo, Hyuk WanKim, HyunhoOh, Yun KyuAhn, CurieKang, Minyong김민정유경현Oh, Goo Taeg박종훈
Issue Date
Oct-2020
Publisher
ELSEVIER
Keywords
Polycystic kidney; PKD; Autophagy; Ift46
Citation
EBIOMEDICINE, v.60, pp 1 - 12
Pages
12
Journal Title
EBIOMEDICINE
Volume
60
Start Page
1
End Page
12
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/1141
DOI
10.1016/j.ebiom.2020.102986
ISSN
2352-3964
2352-3964
Abstract
Background: Polycystic kidney disease (PKD) involves renal cysts arising from proliferating tubular cells. Autophagy has been recently suggested as a potential therapeutic target in PKD, and mammalian target of rapamycin (mTOR) is a key negative regulator of autophagy. However, the effect of autophagy regulation on cystogenesis has not been elucidated in PKD mice. Methods: Clinical validation was performed using GEO datasets and autosomal dominant polycystic kidney disease (ADPKD) patient samples. Newly established PKD and LC3 transgenic mice were used for in vivo verifications, and additional tests were performed in vitro and in vivo using multiple autophagy drugs. Findings: Neither autophagy stimulation nor LC3 overexpression alleviated PKD. Furthermore, we observed the inhibitory effect of an autophagy inhibitor on cysts, indicating its possible therapeutic use in a specific group of patients with ADPKD. Interpretation: Our findings provide a novel insight into the pathogenesis related to autophagy in PKD, suggesting that drugs related to autophagy regulation should be considered with caution for treating PKD. Funding Sources: This work was supported by grants from the Bio & Medical Technology Development Program; the Collaborative Genome Program for Fostering New Post-Genome Industry of the NRF; the Basic Science Program. (c) 2020 The Authors. Published by Elsevier B.V.
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