Dietary Kaempferol Suppresses Inflammation of Dextran Sulfate Sodium-Induced Colitis in Mice
DC Field | Value | Language |
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dc.contributor.author | Park, Mi-Young | - |
dc.contributor.author | Ji, Geun Eog | - |
dc.contributor.author | Sung, Mi-Kyung | - |
dc.date.available | 2021-02-22T12:47:11Z | - |
dc.date.issued | 2012-02 | - |
dc.identifier.issn | 0163-2116 | - |
dc.identifier.issn | 1573-2568 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/11980 | - |
dc.description.abstract | In ulcerative colitis (UC), reduction of inflammation may represent a key mechanism in UC therapy, and anti-inflammatory agents would be good candidates for preventing UC. Kaempferol, a natural flavonoid, is believed to have anti-inflammatory activities and has been shown to be potentially immune-modulatory. The aim of this study was to determine whether kaempferol alleviates the inflammatory responses of dextran sulfate sodium (DSS)-induced colitis in mice. Female C57BL/6J mice were divided into six groups: a negative control group, a DSS control group, and DSS + 0.1% or 0.3% kaempferol pre- or post-fed groups. At the end of the experimental period, clinical and biochemical markers were evaluated. Plasma levels of NO and PGE(2) were significantly decreased in both the 0.3% kaempferol pre- and post-fed groups. The plasma LTB4 level was profoundly decreased in all animals fed kaempferol. Colonic mucosa MPO activity was also suppressed in both the 0.3% kaempferol pre- or post-fed groups. TFF3 mRNA, a marker for goblet cell function, was up-regulated in kaempferol pre-fed animals. These results indicate that kaempferol is an effective anti-inflammatory agent that protects colonic mucosa from DSS-induced UC. Dietary kaempferol fed prior to colitis induction was more effective to suppress some of the colitis-associated markers. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER | - |
dc.title | Dietary Kaempferol Suppresses Inflammation of Dextran Sulfate Sodium-Induced Colitis in Mice | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1007/s10620-011-1883-8 | - |
dc.identifier.scopusid | 2-s2.0-84856715280 | - |
dc.identifier.wosid | 000299487500014 | - |
dc.identifier.bibliographicCitation | DIGESTIVE DISEASES AND SCIENCES, v.57, no.2, pp 355 - 363 | - |
dc.citation.title | DIGESTIVE DISEASES AND SCIENCES | - |
dc.citation.volume | 57 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 355 | - |
dc.citation.endPage | 363 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | BOWEL-DISEASE | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | QUERCETIN | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | Ulcerative colitis (UC) | - |
dc.subject.keywordAuthor | Kaempferol | - |
dc.subject.keywordAuthor | Dextran sulfate sodium (DSS) | - |
dc.subject.keywordAuthor | Inflammation | - |
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