Intestinal Clostridioides difficile Can Cause Liver Injury through the Occurrence of Inflammation and Damage to Hepatocytes
- Authors
- Lee, Soomin; Lee, Heeyoung; Kim, Sejeong; Lee, Jeeyeon; Ha, Jimyeong; Choi, Yukyung; Oh, Hyemin; Kim, Yujin; Lee, Yewon; Choi, Kyoung-Hee; Yoon, Yohan
- Issue Date
- Sep-2020
- Publisher
- HINDAWI LTD
- Citation
- BIOMED RESEARCH INTERNATIONAL, v.2020
- Journal Title
- BIOMED RESEARCH INTERNATIONAL
- Volume
- 2020
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/1236
- DOI
- 10.1155/2020/7929610
- ISSN
- 2314-6133
2314-6141
- Abstract
- This study investigated if intestinalClostridioides difficile(CD) causes liver injury. Four-week-old male C3H/HeN mice were treated with phosphate-buffered solution (control), CD, diethylnitrosamine (DEN) to induce liver injury with PBS (DEN+PBS), and DEN with CD (DEN+CD) for nine weeks. After sacrifice, livers and mesenteric lymph nodes (MLNs) were removed and bacterial translocation, transcriptomes, and proteins were analysed. CD was found in 20% of MLNs from the control and DEN+PBS groups, in 30% of MLNs from the CD group, and in 75% of MLNs from the DEN+CD groups, which had injured livers. Also, CD was detected in 50% of the livers in the DEN+CD group with CD-positive MLNs. ElevatedIL-1 beta,HB-EGF,EGFR,TGF-alpha,PCNA,DES,HMGB1, andCRPexpressions were observed in the CD and DEN+CD groups as compared to the control and DEN+PBS groups. Protein levels of IL-6 and HMGB1 were higher in the CD and DEN+CD groups than in the control and DEN+PBS groups. These results indicate that intestinal CD can initiate and aggravate liver injury, and the mechanism of pathogenesis for liver injury should be investigated in further studies.
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