Inhibition of pentylenetetrazole-induced seizure in mice by using a 4 Hz magnetic field: a comparative study with a 60 Hz magnetic field
- Authors
- Park, Won-Hee; Chae, Young-Joo; Soh, Kwang-Sup; Lee, Byung-Cheon; Pyo, Myoung-Yun
- Issue Date
- Dec-2012
- Publisher
- INFORMA HEALTHCARE
- Keywords
- 4 Hz magnetic field; 60 Hz magnetic field; Seizure; Pentylenetetrazole; Oxidative stress
- Citation
- ELECTROMAGNETIC BIOLOGY AND MEDICINE, v.31, no.4, pp 293 - 298
- Pages
- 6
- Journal Title
- ELECTROMAGNETIC BIOLOGY AND MEDICINE
- Volume
- 31
- Number
- 4
- Start Page
- 293
- End Page
- 298
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/12410
- DOI
- 10.3109/15368378.2012.662191
- ISSN
- 1536-8378
1536-8386
- Abstract
- We investigated the comparative effects of 4 and 60 Hz magnetic fields on pentylenetetrazole (PTZ)-induced seizure in mice. For this study, we measured the latent time to seizure, seizure duration, and lethality induced by PTZ in mice exposed to 4 and 60 Hz magnetic fields (MF) for 30 min. Compared to sham-exposed controls, the latent time to tail twitching and seizure in the 4 Hz MF group was significantly decreased while the latent time to seizure in the 60 Hz MF group was significantly increased. The seizure duration in the 4 Hz MF group was significantly decreased while that in the 60 Hz MF group was significantly increased. More importantly, while the mice exposed to a 60 Hz MF experienced significantly increased lethality after seizure convulsion, those exposed to a 4 Hz MF showed no lethality, with a shortening of the duration of seizure. This beneficial effect of a 4 Hz MF on seizure has the same implication as the anti-oxidative effects of a 4 Hz MF observed in our previous work. The results of our current and previous works indicate that a 4 Hz MF may be used as a therapeutic physical agent for the treatment of oxidative stress-induced diseases, including seizure, with or without chemical drugs.
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