Vascular tube formation and angiogenesis induced by polyvinylpyrrolidone-coated silver nanoparticles
- Authors
- Kang, Kyeongah; Lim, Dae-Hyoun; Choi, In-Hong; Kang, Taegyeong; Lee, Kangtaek; Moon, Eun-Yi; Yang, Young; Lee, Myeong-Sok; Lim, Jong-Seok
- Issue Date
- Sep-2011
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Silver nanoparticles; Matrigel plug; Angiogenesis; Vascular endothelial growth factor; VEGF signaling
- Citation
- TOXICOLOGY LETTERS, v.205, no.3, pp 227 - 234
- Pages
- 8
- Journal Title
- TOXICOLOGY LETTERS
- Volume
- 205
- Number
- 3
- Start Page
- 227
- End Page
- 234
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/12496
- DOI
- 10.1016/j.toxlet.2011.05.1033
- ISSN
- 0378-4274
1879-3169
- Abstract
- Silver nanoparticles (AgNPs) are one of the most commonly used nanomaterials due to their antibacterial properties. In this study, we examined the effects of polyvinylpyrrolidone (PVP)-coated AgNPs (average size 2.3 nm) on angiogenesis in both an in vivo model and an in vitro endothelial cell line, SVEC4-10. Increased angiogenesis was detected around the injection site of AgNP-containing Matrigel in vivo. AgNPs also increased the infiltration of endothelial cells and the hemoglobin (Hb) content in AgNP-Matrigel plugs implanted into mice. AgNPs induced endothelial cell tube formation on growth factor-reduced Matrigel, production of reactive oxygen species (ROS), and production of angiogenic factors, such as vascular endothelial growth factor (VEGF) and nitric oxide (NO), in SVEC4-10 cells. In addition, AgNPs promoted the activation of FAK, Akt, ERK1/2, and p38, which are all involved in VEGF receptor (VEGFR)-mediated signaling. Finally, AgNP-treated tumors caused angiogenesis around tumors in B16F10 melanomas after they were injected into mice, and the Hb concentration in the tumors increased in a concentration-dependent manner with AgNP treatment. Thus, our study suggests that exposure to AgNPs can cause angiogenesis through the production of angiogenic factors. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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