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In Vitro Antiinflammatory Activity of a New Sesquiterpene Lactone Isolated from Siegesbeckia glabrescens
- Authors
- Li, Hua; Kim, Jae Yeon; Hyeon, Jinseong; Lee, Hwa Jin; Ryu, Jae-Ha
- Issue Date
- Sep-2011
- Publisher
- WILEY
- Keywords
- nitric oxide; prostaglandin E-2; nuclear factor-kappa B; Siegesbeckia glabrescens; sesquiterpenes; inhibitor
- Citation
- PHYTOTHERAPY RESEARCH, v.25, no.9, pp 1323 - 1327
- Pages
- 5
- Journal Title
- PHYTOTHERAPY RESEARCH
- Volume
- 25
- Number
- 9
- Start Page
- 1323
- End Page
- 1327
- ISSN
- 0951-418X
1099-1573
- Abstract
- A new sesquiterpene lactone was isolated from Siegesbeckia glabrescens as an inhibitor of nitric oxide and prostaglandin E-2 synthesis in the LPS-activated RAW264.7 macrophage cell line. It dose-dependently decreased the protein and mRNA levels of inducible nitric oxide synthase and cyclooxygenase-2. Reporter gene assay revealed that the compound attenuated the LPS-induced DNA transcriptional activity of nuclear factor-kappa B (NF-kappa B). In addition, it inhibited the nuclear translocation of the p65 subunit of NF-kappa B by blocking the inhibitory kappa B-alpha degradation. This compound from Siegesbeckia glabrescens might be beneficial for the treatment of inflammation-related diseases. Copyright (C) 2011 John Wiley & Sons, Ltd.
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