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New estrogenic compounds isolated from Broussonetia kazinoki
- Authors
- Lee, Da Yeon; Kim, Do Hee; Lee, Hwa Jin; Lee, YoungJoo; Ryu, Kwang Hee; Jung, Bo-In; Song, Yun Seon; Ryu, Jae-Ha
- Issue Date
- 15-Jun-2010
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Estrogen receptor; Phytoestrogen; Broussonetia kazinoki
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.20, no.12, pp 3764 - 3767
- Pages
- 4
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 20
- Number
- 12
- Start Page
- 3764
- End Page
- 3767
- ISSN
- 0960-894X
1464-3405
- Abstract
- Two new and two known compounds were identified as estrogenic constituents from Broussonetia kazinoki. Their structures were elucidated as broussonin A (1), tupichinol C (2), kazinol U (3), and (+)-(2R) kazinol I (4). They showed estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. They also control the cellular gene expression levels of estrogen-responsive genes. Phytoestrogens from B. kazinoki may have beneficial effects in the treatment of menopausal symptoms. (C) 2010 Elsevier Ltd. All rights reserved.
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