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New estrogenic compounds isolated from Broussonetia kazinoki

Authors
Lee, Da YeonKim, Do HeeLee, Hwa JinLee, YoungJooRyu, Kwang HeeJung, Bo-InSong, Yun SeonRyu, Jae-Ha
Issue Date
15-Jun-2010
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
Estrogen receptor; Phytoestrogen; Broussonetia kazinoki
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.20, no.12, pp.3764 - 3767
Journal Title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume
20
Number
12
Start Page
3764
End Page
3767
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13186
DOI
10.1016/j.bmcl.2010.04.064
ISSN
0960-894X
Abstract
Two new and two known compounds were identified as estrogenic constituents from Broussonetia kazinoki. Their structures were elucidated as broussonin A (1), tupichinol C (2), kazinol U (3), and (+)-(2R) kazinol I (4). They showed estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. They also control the cellular gene expression levels of estrogen-responsive genes. Phytoestrogens from B. kazinoki may have beneficial effects in the treatment of menopausal symptoms. (C) 2010 Elsevier Ltd. All rights reserved.
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