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Suppression of Inducible Nitric Oxide Synthase Expression by Furfuran Lignans from Flower Buds of Magnolia fargesii in BV-2 Microglial Cells

Authors
Kim, Ji SunKim, Jae YeonLee, Hwa JinLim, Hyo JinLee, Da YeonKim, Do HeeRyu, Jae-Ha
Issue Date
May-2010
Publisher
WILEY
Keywords
nitric oxide synthase; Magnolia fargesii; microglia; peroxynitrite
Citation
PHYTOTHERAPY RESEARCH, v.24, no.5, pp.748 - 753
Journal Title
PHYTOTHERAPY RESEARCH
Volume
24
Number
5
Start Page
748
End Page
753
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13216
DOI
10.1002/ptr.3028
ISSN
0951-418X
Abstract
Activated microglia produces diverse neurotoxic factors such as nitric oxide (NO) and tumor necrosis factor-a that serve as apoptotic inducers resulting in various neurodegenerative diseases. The inhibition of microgliaderived NO production by inducible nitric oxide synthase (iNOS) has been reported to be beneficial in retarding neurodegenerative disorders. Three active lignans have been isolated from the flower buds of Magnolia fargesii by the bioassay-guided fractionation using lipopolysaccharide (LPS)-activated BV-2 microglial cell culture system. The structures of them were identified as kobusin (1), aschantin (2) and fargesin (3) by the analyses of spectroscopic data. They inhibited the production of NO by activated microglia. Their IC50 values were 21.8 +/- 3.7, 14.8 +/- 2.5 and 10.4 +/- 2.8 Ltg/mL, respectively. They suppressed LPS-induced NF-kappa B activation and the expression of iNOS protein and mRNA. Furthermore, they showed scavenging activity of neurotoxic peroxynitrite that can be produced by NO and superoxide anion. These results imply that lignans from Magnolia fargesii might be beneficial for the treatment of neuro-inflammatory diseases through the inhibition of iNOS expression and peroxynitrite scavenging potential. Copyright (C) 2009 John Wiley & Sons, Ltd.
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