뇌졸중환자를 중심한 산화적 손상지표의 양상

Abstract

Oxidative stress has been emphasized as a molecular etiology for degenerative disease and various biomarkers to measure oxidative stress have been developed. Among them, hyperhomocysteinemia has been focused as a risk factor for stroke. However, there are still discrepancies for the roles of homocysteine on stroke. In the present study, we analyzed oxidative stress levels with malondialdehyde (MDA) and homocysteine levels in chronic male stroke patients (N=7; age, 65.5 ± 6.0 yrs) due to progress of stroke (for 6 months). In addition, vitamin B12, a chemopreventive candidate, has been analyzed to study its effects on MDA or homocysteine. As results, MDA levels were increased due to time period (0.05<p<0.1) and were positively associated with homocysteine levels (p<0.001). However, vitamin B12 did not show any negative association with MDA or homocysteine. In conclusion, we found increased oxidative stress due to stroke progress. Based on positive association with MDA, homocysteine may be involved in oxidative damage during stroke progress. This finding provides a useful mechanism to develop anti oxidative materials to protect stroke.