Bisphenol A 노출과 소아 내분비계 질환에 관한 우리나라 여아에서의 Pilot StudyExposure to Bisphenol A and Girls’ Endocrine Disorders
- Other Titles
- Exposure to Bisphenol A and Girls’ Endocrine Disorders
- Authors
- 김수진; 이빛나; 박미정; 신혜정; 양미희
- Issue Date
- Jun-2010
- Publisher
- 대한암예방학회
- Keywords
- Bisphenol A; Children; Endocrine disorders; Sexual precocity; Premature thelarche; Girls
- Citation
- 대한암예방학회지, v.15, no.2, pp 106 - 110
- Pages
- 5
- Journal Title
- 대한암예방학회지
- Volume
- 15
- Number
- 2
- Start Page
- 106
- End Page
- 110
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13504
- ISSN
- 2288-3649
2288-3657
- Abstract
- Maternal or childhood exposure to chemical carcinogens has been suspected to develop cancers in adults.
Particularly, exposure to bisphenol A (BPA), an endocrine disrupting chemical, in early age showed increase of endocrine-related cancers in adults through animal models. Thus, we performed biomonitoring of BPA and studied effects of BPA exposure on endocrine disorders in Korean girls. Urine samples were collected from age matched girls (n=38), who were endocrine disordered patients (n=25, 8.36±1.18 years) or were healthy controls (n=13, 8.36±1.33 years). Urinary BPA was analyzed with HPLC/FLD. Limit of detection (LOD) of BPA was 0.4μg/l. As results, ranges of urinary BPA were 0.25∼49.56μg/g creatinine (median,4.67 μg/g creatinine). Urinary BPA was detected among 71.05% of the subjects. There were no differences in urinary BPA between the patients and the controls (9.41±12.25 vs. 5.44±4.53μg/g creatinine, p=0.65)or between the controls and sexual precocity- or premature thelarche-patients (p=0.84; p=0.37, respectively).
Thus, our pilot study suggests that girls’ endocrine disorders, e.g. sexual precocity- or premature thelarche,may be not the end points of BPA exposure. (Cancer Prev Res 15, 106-110, 2010)
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