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Dexamethasone에 의한 RANKL 유도성 파골세포 분화 촉진 효과The Stimulatory Effect of Dexamethasone on RANKL-induced Osteoclastogenesis
- Other Titles
- The Stimulatory Effect of Dexamethasone on RANKL-induced Osteoclastogenesis
- Issue Date
- Apr-2009
- Publisher
- 대한약학회
- Keywords
- glucocorticoid; dexamethasone; osteoclast; IFN-β
- Citation
- 약 학 회 지, v.53, no.2, pp 78 - 82
- Pages
- 5
- Journal Title
- 약 학 회 지
- Volume
- 53
- Number
- 2
- Start Page
- 78
- End Page
- 82
- ISSN
- 0377-9556
- Abstract
- We explored the effects of dexamethasone on osteoclast precursors using BMMs. Dexamethasone inhibited the proliferation of BMMs. Furthermore, it stimulated the osteoclast formation via NFATc1 activation in the presence of RANKL. Since dexamethasone targeted the early stage of osteoclast formation, we investigated its effect on mRNA expression of GR and IFN-β. Whereas dexamethasone had no effects on GR expression in the presence of RANKL, it reduced the expression of IFN-β, suggesting that dexamethasone increased RANKL-induced osteoclast formation by modulating IFN-β.
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