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Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by xanthanolides isolated from Xanthium strumarium
- Issue Date
- 15-Mar-2008
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- nitric oxide synthase; cyclooxygenase; Xanthium strumarium; sesquiterpene; nuclear factor kappa B
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.18, no.6, pp 2179 - 2182
- Pages
- 4
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 18
- Number
- 6
- Start Page
- 2179
- End Page
- 2182
- ISSN
- 0960-894X
1464-3405
- Abstract
- Three sesquiterpenoids, xanthatin (1), xanthinosin (2), and 4-oxo-bedfordia acid (3) were isolated from Xanthium strumarium as inhibitors of nitric oxide synthesis in activated microglia (IC50 values: 0.47, 11.2, 136.5 mu M, respectively). Compounds 1 and 2 suppressed the expression of iNOS and COX-2 and the activity of NF-kappa B through the inhibition of LPS-induced I-kappa B-alpha degradation in microglia. (C) 2008 Elsevier Ltd. All rights reserved.
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