서울 거주 산모의 초유 중 노닐페놀 분석을 통한 인체노출평가

Abstract

Biomonitoring of nonylphenol (NP), an endocrine disrupting chemical, is required in Korea to perform itsproper regulation. Thus, we analyzed exposure levels of nonlyphenol(NP) in breast milk from the mothers whodelivered babies within 10 days (N= 325). We analyzed free and total forms of NP in breast milk withLC/MS/MS (LOD, 0.5 ppb). In addition, we obtained questionnaires concerning lifestyle from the subject. Asresults, ranges of total NP were LOD-23.4g/L (median, LOD) and the estimated exposure level of theNP was lower than TDI (tolerable daily intake)s. However, we found that the levels of total NP in the mothers,who had some diseases such as thyroid disorders, were higher than those in healthy mothers (sick mothers,N= 34, 3.51± 4.98g/L vs. normal, N= 281, 2.07± 3.76g/L; p0.05). In conclusion, we suggest that expo-sure monitoring of NP should be continuously performed, even though the risks of NP are not clear, yet.