열처리 배즙이 마우스의 비장세포 증식능과 Cytokine 생성능에 미치는 영향Effects of Heated Pear Juice on the Proliferation and Cytokines Production of Mouse Splenocytes in vitro
- Other Titles
- Effects of Heated Pear Juice on the Proliferation and Cytokines Production of Mouse Splenocytes in vitro
- Authors
- 황유경; 양미희; 표명윤
- Issue Date
- Mar-2008
- Publisher
- 대한암예방학회
- Keywords
- Heated pear juice; Splenocytes proliferation; IFN-γ; IL-4; Heated pear juice; Splenocytes proliferation; IFN-γ; IL-4
- Citation
- 대한암예방학회지, v.13, no.1, pp 68 - 73
- Pages
- 6
- Journal Title
- 대한암예방학회지
- Volume
- 13
- Number
- 1
- Start Page
- 68
- End Page
- 73
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14516
- ISSN
- 2288-3649
2288-3657
- Abstract
- A Pear (Pyrus pyrifolia N.) is a popular fruit in Korea and has been used as a folk remedy for constipation, cold, fever, cough, etc. This study was performed to investigate the potential of pear as a immune-modulating functional food by assay of splenocytes proliferation and induction of cytokine (IFN-γ, IL-4) in vitro. When mouse splenocytes were exposed to various concentration (0.16, 0.31, 0.63, 1.25, 2.50 mg/ml) of heated pear juice (HP) without or with mitogens (Con A, LPS), splenocytes proliferation (SP) was significantly increased when compared with each control. When splenocytes were cultured with HP in the presence of T cell mitogen (Con A), IFN-γ and IL-4 levels in culture supernatant were significantly enhanced at 1.25 mg/ml when compared with control group. Therefore, our results suggest that the heated pear juice may have the potential of being an immune-modulating functional food. (Cancer Prev Res 13, 68-73, 2008)
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