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SUMOylation of pontin chromatin-remodeling complex reveals a signal integration code in prostate cancer cells

Authors
Kim, Jung HwaLee, A. MinNam, Hye JinChoi, Hee JuneYang, Jung WooLee, Jason S.Kim, Mi HyangKim, Su-IlChung, Chin HaKim, Keun IlBaek, Sung Hee
Issue Date
Dec-2007
Publisher
NATL ACAD SCIENCES
Keywords
androgen receptor; SUMO; Ubc9; transcription; proliferation
Citation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.104, no.52, pp.20793 - 20798
Journal Title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume
104
Number
52
Start Page
20793
End Page
20798
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14591
DOI
10.1073/pnas.0710343105
ISSN
0027-8424
Abstract
Posttranslational modification by small ubiquitin-like modifier (SUMO) controls diverse cellular functions of transcription factors and coregulators and participates in various cellular processes including signal transduction and transcriptional regulation. Here, we report that pontin, a component of chromatin-remodeling complexes, is SUMO-modified, and that SUMOylation of pontin is an active control mechanism for the transcriptional regulation of pontin on androgen-receptor target genes in prostate cancer cells. Biochemical purification of pontin-containing complexes revealed the presence of the Ubc9 SUIVIO-conjugating enzyme that underlies its function as an activator. Intriguingly, 5 alpha-dihydroxytestosterone treatments significantly increased the SUMOylation of pontin, and SUMOylated pontin showed further activation of a subset of nuclear receptor-dependent transcription and led to an increase in proliferation and growth of prostate cancer cells. These data clearly define a functional model and provide a link between SUMO modification and prostate cancer progression.
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