SUMOylation of pontin chromatin-remodeling complex reveals a signal integration code in prostate cancer cells
- Authors
- Kim, Jung Hwa; Lee, A. Min; Nam, Hye Jin; Choi, Hee June; Yang, Jung Woo; Lee, Jason S.; Kim, Mi Hyang; Kim, Su-Il; Chung, Chin Ha; Kim, Keun Il; Baek, Sung Hee
- Issue Date
- Dec-2007
- Publisher
- NATL ACAD SCIENCES
- Keywords
- androgen receptor; SUMO; Ubc9; transcription; proliferation
- Citation
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.104, no.52, pp 20793 - 20798
- Pages
- 6
- Journal Title
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Volume
- 104
- Number
- 52
- Start Page
- 20793
- End Page
- 20798
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14591
- DOI
- 10.1073/pnas.0710343105
- ISSN
- 0027-8424
1091-6490
- Abstract
- Posttranslational modification by small ubiquitin-like modifier (SUMO) controls diverse cellular functions of transcription factors and coregulators and participates in various cellular processes including signal transduction and transcriptional regulation. Here, we report that pontin, a component of chromatin-remodeling complexes, is SUMO-modified, and that SUMOylation of pontin is an active control mechanism for the transcriptional regulation of pontin on androgen-receptor target genes in prostate cancer cells. Biochemical purification of pontin-containing complexes revealed the presence of the Ubc9 SUIVIO-conjugating enzyme that underlies its function as an activator. Intriguingly, 5 alpha-dihydroxytestosterone treatments significantly increased the SUMOylation of pontin, and SUMOylated pontin showed further activation of a subset of nuclear receptor-dependent transcription and led to an increase in proliferation and growth of prostate cancer cells. These data clearly define a functional model and provide a link between SUMO modification and prostate cancer progression.
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