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Cell-specific activation of gemcitabine by endogenous H2S stimulation and tracking through simultaneous fluorescence turn-on
- Issue Date
- Sep-2021
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.57, no.75, pp 9614 - 9617
- Pages
- 4
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 57
- Number
- 75
- Start Page
- 9614
- End Page
- 9617
- ISSN
- 1359-7345
1364-548X
- Abstract
- The endogenous H2S-driven theranostic H2S-Gem has been invented. The theranostic prodrug H2S-Gem is selectively activated in cancer cells, releasing active gemcitabine with a simultaneous fluorescence turn-on. H2S-Gem selectively inhibited cancer cell growth compared to the mother chemotherapeutic gemcitabine. Overall, it is a unique protocol for tracking and transporting chemotherapeutic agents to tumor areas without the guidance of tumor-directive ligands.
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