Detailed Information

Cited 0 time in webofscience Cited 3 time in scopus
Metadata Downloads

Therapeutic efficacy of DNA-loaded PLGA microspheres in tumor-bearing mice

Authors
Son, Hye-JungKim, Jin-Seok
Issue Date
Aug-2007
Publisher
PHARMACEUTICAL SOC KOREA
Keywords
microsphere; PLGA; cancer gene therapy; CT-26; 5-fluorouracil (5-FU)
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.30, no.8, pp.1047 - 1050
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
Volume
30
Number
8
Start Page
1047
End Page
1050
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14660
DOI
10.1007/BF02993975
ISSN
0253-6269
Abstract
In vivo gene therapy was attempted using poly-(D,L-lactic-co-glycolic. acid) microspheres containing the interleukin-12 gene (p2CMVmIL12) in colon adenocarcinoma (CT-26)-bearing Balb/ c mice. Treatment with IL-12-loaded microspheres inhibited tumor growth significantly compared to a control group treated with free IL-12 DNA, though the degree of tumor inhibition was not dependent on the amount of IL-12 gene loaded. Combining gene therapy with 5-fluorouracil (50 mg/kg) treatment further inhibited tumor growth compared with gene therapy alone. The results indicate that microsphere formulations of pDNA may provide an efficient gene delivery system.
Files in This Item
There are no files associated with this item.
Appears in
Collections
약학대학 > 약학부 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Jin Seok photo

Kim, Jin Seok
약학대학 (약학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE