Maternal folic acid supplementation modulates DNA methylation and gene expression in the rat offspring in a gestation period-dependent and organ-specific manner
- Authors
- Ly, A (Ly, Anna); Ishiguro, L (Ishiguro, Lisa); Kim, D (Kim, Denise); Im, D (Im, David); Kim, SE (Kim, Sung-Eun); Sohn, KJ (Sohn, Kyoung-Jin); Croxford, R (Croxford, Ruth); Kim, YI (Kim, Young-In)
- Issue Date
- Jul-2016
- Publisher
- ELSEVIER SCIENCE INC
- Citation
- JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v.33, pp 103 - 110
- Pages
- 8
- Journal Title
- JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Volume
- 33
- Start Page
- 103
- End Page
- 110
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/147045
- DOI
- 10.1016/j.jnutbio.2016.03.018
- ISSN
- 0955-2863
1873-4847
- Abstract
- Maternal folic acid supplementation can alter DNA methylation and gene expression in the developing fetus, which may confer disease susceptibility later in life. We determined which gestation period and organ were most sensitive to the modifying effect of folic acid supplementation during pregnancy on DNA methylation and gene expression in the offspring. Pregnant rats were randomized to a control diet throughout pregnancy; folic acid supplementation at 2.5 x the control during the 1st, 2nd or 3rd week of gestation only; or folic acid supplementation throughout pregnancy. The brain, liver, kidney and colon from newborn pups were analyzed for folate concentrations, global DNA methylation and gene expression of the Igf2, Er-alpha, Gr, Ppar-alpha and Ppar-gamma genes. Folic acid supplementation during the 2nd or 3rd week gestation or throughout pregnancy significantly increased brain folate concentrations (P<.001), while only folic acid supplementation throughout pregnancy significantly increased liver folate concentrations (P=.005), in newborn pups. Brain global DNA methylation incrementally decreased from early to late gestational folic acid supplementation and was the lowest with folic acid supplementation throughout pregnancy (P=.026). Folic acid supplementation in late gestation or throughout pregnancy signific
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 생활과학대학 > 식품영양학과 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.