Dietary effects of structured lipids and phytosteryl esters on cardiovascular function in spontaneously hypertensive rats
- Authors
- 김병희; Sandock, Kevin D.; Robertson, Toni P; Lewis, Stephen J.; Akoh, Casimir C.
- Issue Date
- Aug-2007
- Publisher
- Lippincott Williams & Wilkins
- Keywords
- α1- and β-adrenoceptors; Baroreceptor reflex; Endothelium-dependent vasodilation; High-fat diets; Nitric oxide; Phytosteryl esters; Sesame oil; Spontaneously hypertensive rats; Structured lipids
- Citation
- Journal of Cardiovascular Pharmacology , v.50, no.2, pp 176 - 186
- Pages
- 11
- Journal Title
- Journal of Cardiovascular Pharmacology
- Volume
- 50
- Number
- 2
- Start Page
- 176
- End Page
- 186
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/148376
- DOI
- 10.1097/FJC.0b013e31805d8f03
- ISSN
- 0160-2446
1533-4023
- Abstract
- This study examined the dietary effects of sesame oil (SO)-based structured lipids (SL) and phytosteryl esters (PE) on cardiovascular function in conscious spontaneously hypertensive rats (SHR) fed high-fat (HF) diets (20% w/w fat). The dietary groups were as follows: nortual diet (4.5% w/w fat), SO, SO fortified with PE (SOP), SL, and SL fortified with PE (SLP). Mean arterial blood pressures were similar in all groups, whereas resting heart rates (HR) were higher in all HF-fed groups. The pressor responses to the alpha 1-adrenoceptor agonist, phenylephrine (5 mu g/kg), were similar in all groups. However, the pressor responses to phenylephrine (10 mu g/kg) were diminished in SO- or SL-fed SHR, whereas they were not diminished in SOP- or SLP-fed SHR. The depressor responses elicited by the nitric oxide (NO) donor, sodium nitroprusside (5 and 10 mu g/kg), were not diminished in HF-fed rats. Baroreflex-mediated changes in HR were variously decreased in the HF-fed groups, and this decrease tended to be greater in SOP and SLP than in SO and SL groups. The depressor and tachycardic responses elicited by the P-adrenoceptor agonist, isoproterenol, were equivalent in all groups. The depressor responses elicited by the endothelium-dependent agonist, acetylcholine (0. 1 mu g/kg), and the hypertension elicited by the NO synthesis inhibitor, N-G-nitro-L-arginine methylester (25 mu mol/kg), were similar in all groups. These findings demonstrate that (1) HF diets increase resting HR and impair baroreflex function in SHR, whereas they do not obviously affect endothelium-dependent vasodilation, and (2) fortification with PE may be deleterious to cardiovascular function (eg, baroreflex activity) in SHR.
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