The inhibitory effects of eckol and dieckol from Ecklonia stolonifera on the expression of matrix metalloproteinase-1 in human dermal fibroblasts.
- Authors
- Min-Jeong JOE; Su-Nam KIM; Hye-Young CHOI; Woon-Seob SHIN; Gab-Man PARK; Dong-Won KANG; Kim, Yong Kee
- Issue Date
- Aug-2006
- Publisher
- Pharmaceutical Society of Japan
- Citation
- Biological and Pharmaceutical Bulletin, v.29, no.8, pp 1735 - 1739
- Pages
- 5
- Journal Title
- Biological and Pharmaceutical Bulletin
- Volume
- 29
- Number
- 8
- Start Page
- 1735
- End Page
- 1739
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/148572
- DOI
- 10.1248/bpb.29.1735
- ISSN
- 0918-6158
1347-5215
- Abstract
- In order to develop new anti-photoaging agents, we examined the inhibitory effects of 29 seaweed extracts on transcriptional activities of NF-kappa B and AP-1, and MMP-1 expression. The extracts from 3 species of Alariaceae, Eisenia bicyclis, Ecklonia cava and Ecklonia stolonifera, have showed strong inhibition of both NF-kappa B and AP-1 reporter activity, which were well correlated with their abilities to inhibit MMP-1 expression. In addition, MMP-1 expression was dramatically attenuated by treatment with eckol or dieckol which were purely isolated from E. stolonifera, indicating that these compounds are active principles to inhibit MMP-1 expression in human dermal fibroblasts. Taken together, our data demonstrate the inhibitory effect of eckol and dieckol from Ecklonia species on MMP-1 expression in human dermal fibroblasts and provide a possibility to develop as an agent for the prevention and treatment of skin aging.
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