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RpS3, a DNA repair endonuclease and ribosomal protein, is involved in apoptosis.DNA repair endonuclease이고 ribosomal protein인 rpS3는 apoptosis에 관여한다.
- Other Titles
- DNA repair endonuclease이고 ribosomal protein인 rpS3는 apoptosis에 관여한다.
- Authors
- Jang, Chang Young; Lee, Jae Yung; Kim, Joon
- Issue Date
- Feb-2004
- Publisher
- Federation of European Biochemical Societies
- Citation
- FEBS Letters - 직접입력, v.560, no.1-3, pp 81 - 85
- Pages
- 5
- Journal Title
- FEBS Letters - 직접입력
- Volume
- 560
- Number
- 1-3
- Start Page
- 81
- End Page
- 85
- ISSN
- 0014-5793
1873-3468
- Abstract
- It is known that mammalian rpS3 functions as a DNA repair endonuclease and ribosomal protein S3. It was also observed that several ribosomal proteins or DNA repair enzymes are related to apoptosis. We report here a third function of rpS3, induction of apoptosis. The localization of green fluorescent protein (GFP)-rpS3 is changed to the nuclear membrane when lymphocytic cells undergo rpS3-induced apoptosis. Transient expression of GFP-rpS3 activates caspase-8/caspase-3 and sensitizes cytokine-induced apoptosis. Deletion analysis reveals that the two functions of rpS3, DNA repair and apoptosis, use independent functional domains.
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