Enzymatic synthesis of tea theaflavin derivatives and their anti-inflammatory and cytotoxic activities
- Authors
- Shengmin Sang; Joshua D. Lambert; Shiying Tian; Jungil Hong; Zhe Hou; Ryu, Jae Ha; Ruth E. Stark; Robert T. Rosen; Mou-Tuan Huang; Chung S. Yanga; Chi-Tang Hob
- Issue Date
- Jan-2004
- Publisher
- Elsevier
- Citation
- Bioorganic & medicinal chemistry, v.12, no.2, pp 459 - 467
- Pages
- 9
- Journal Title
- Bioorganic & medicinal chemistry
- Volume
- 12
- Number
- 2
- Start Page
- 459
- End Page
- 467
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/148987
- DOI
- 10.1016/j.bmc.2003.10.024
- ISSN
- 0968-0896
1464-3391
- Abstract
- Derivatives based on a benzotropolone skeleton (9–26) have been prepared by the enzymatic coupling (horseradish peroxidase/H2O2) of selected pairs of compounds (1–8), one with a vic-trihydroxyphenyl moiety, and the other with an ortho-dihydroxyphenyl structure. Some of these compounds have been found to inhibit TPA-induced mice ear edema, nitric oxide (NO) synthesis, and arachidonic acid release by LPS-stimulated RAW 264.7 cells. Their cytotoxic activites against KYSE 150 and 510 human esophageal squamous cell carcinoma and HT 29 human colon cancer cells were also evaluated.
Derivatives based on a benzotropolone skeleton (9–26) have been prepared by the enzymatic coupling (horseradish peroxidase/H2O2) of selected pairs of compounds (1–8), one with a vic-trihydroxyphenyl moiety, and the other with an ortho-dihydroxyphenyl structure. Some of these compounds have been found to inhibit TPA-induced mice ear edema, nitric oxide (NO) synthesis, and arachidonic acid release by LPS-stimulated RAW 264.7 cells. Their cytotoxic activities against KYSE 150 and 510 human esophageal squamous cell carcinoma and HT 29 human colon cancer cells were also evaluated.
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