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Biological effects of G1 phase arrest compound, sesquicillin, in human breast cancer cell lines
- Issue Date
- Oct-2002
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY, v.10, no.10, pp 3129 - 3134
- Pages
- 6
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY
- Volume
- 10
- Number
- 10
- Start Page
- 3129
- End Page
- 3134
- ISSN
- 0968-0896
1464-3391
- Abstract
- Sesquicillin, isolated from fungal fermentation broth, strongly induced G1 phase arrest in human breast cancer cells. During G1 phase arrest, the expression level of cyclin D1, cyclin A, and cyclin E was decreased, and the expression of CDK (cyclin-dependent-kinase) inhibitor, protein p21(Waf1/CiP1), was increased in a time-dependent manner in a breast cancer cell MCF-7. Interestingly, the G1 phase arrest induced by sesquicillin also occurred independently of the tumor suppressor protein, p53. Sesquicillin inhibits the proliferation of MCF-7 via G1 phase arrest in association with the induction of CDK inhibitor protein, p21(waf1/CiP1), and the reduction of G1 phase related-cyclin proteins. (C) 2002 Elsevier Science Ltd. All rights reserved.
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