Effects of lifestyle on urinary 1-hydroxypyrene concentration
- Authors
- Kawamoto T.; Yang M.; Kim Y.-D.; Kim H.; Oyama T.; Isse T.; Matsuno K.; Katoh T.; Uchiyama I.
- Issue Date
- Jun-2007
- Keywords
- 1-Hydroxypyrene; Alcohol; Biological monitoring; Biomarkers; Dietary balance; Fish; Meat; PAH (polyaromatic hydrocarbon); Smoking; Vegetable
- Citation
- Journal of Occupational Health, v.49, no.3, pp 183 - 189
- Pages
- 7
- Journal Title
- Journal of Occupational Health
- Volume
- 49
- Number
- 3
- Start Page
- 183
- End Page
- 189
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14969
- DOI
- 10.1539/joh.49.183
- ISSN
- 1341-9145
1348-9585
- Abstract
- This study aimed to clarify the variation of urinary excretion of 1-hydroxypyrene, which is a major metabolite of pyrene, in relation to lifestyle, including factors such as diet and smoking. The study subjects were 251 workers (male: 196, female: 55, mean age: 44.3) who were not occupationally exposed to PAHs. Urine specimens were collected from 8:00 a.m. to 11:00 a.m. and their 1-hydroxypyrene concentrations were determined by HPLC. A questionnaire was distributed in order to learn gross aspects of the subjects' lifestyles, i.e., smoking, alcohol consumption, coffee/black tea intake, and dietary habits. Multiple linear regression analysis revealed that cigarette consumption most strongly affected the 1-hydroxypyrene level in urine, followed by dietary balance. The urinary 1-hydroxypyrene concentrations of smokers were about 2 times higher than those of non-smokers. Subjects who ate more meat and/or fish excreted 1.5-2 times more 1-hydroxypyrene in urine than those who ate more vegetables.
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