한국인의 고지혈증과 cetp 및 apoe유전자다형

Abstract

Since 1980s, hyperlipidemia in Korea has been rapidly increased and its related cardiovascular diseases are one of the main causes of death in Korea. Thus, for effective prevention of hyperlipidemia, clarification of etiology of the hyperlipidemia in Koreans is required. In this study, we focused on polymorphisms in genes, which are involved in cholesterol-transfer, and -binding, e.g. cholesteryl ester transfer protein (CETP) and apolipoprotein E (APOE). Study subjects were 257 Koreans (cases who had hyperlipidemia, LDL≥130, N=47; controls, N=210; Men, 62%). Genetic polymorphisms were determined by PCR-RFLP, and single base primer extension assays. As results, allele frequency of the CETP -Tag IB1 was significantly higher in cases than that in controls (p<0.05). When age and BMI were controled for statistics, there was 2.3 fold increase of OR (95%CI, 1.1-5.1) for hyperlipidemia in the Bl/Bl homozygotes compated to the B1/B2 heterozygotes. However, 2 SNPs, CI 12R and R158C of the APOE, or 5 haplotypes of the 2 SNPs were not associated with hyperlipidemia risk. Therefore, presence of the CETP-B1 allele has a potential of risk for Korean hyperlipidemia.