Korean red ginseng rootlets decrease acute postprandial glycemia: Results from sequential preparation- and dose-finding studies
DC Field | Value | Language |
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dc.contributor.author | Sievenpiper, JL | - |
dc.contributor.author | Sung, MK | - |
dc.contributor.author | Di Buono, M | - |
dc.contributor.author | Seung-Lee, K | - |
dc.contributor.author | Nam, KY | - |
dc.contributor.author | Arnason, JT | - |
dc.contributor.author | Leiter, LA | - |
dc.contributor.author | Vuksan, V | - |
dc.date.available | 2021-02-22T15:30:58Z | - |
dc.date.issued | 2006-04 | - |
dc.identifier.issn | 0731-5724 | - |
dc.identifier.issn | 1541-1087 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15155 | - |
dc.description.abstract | Background: Fractionation of a ginseng source to produce differences in the ginsenoside profile might influence its effect on postprandial glycemia. To explore this possibility and identify an efficacious ginseng for a longterm study, we conducted a preparation-finding study of different Korean red ginseng (KRG) root fractions followed by a dose-finding study of the most efficacious fraction. Methods: A double-blind, randomized, within-subject design was used in both studies. In the preparation-finding study, 7 healthy subjects (sex: 3m:4f, age: 32 +/- 4 y, BMI: 24 +/- 2 kg/m(2)) received 6 g placebo and KRG-rootlets, -body, and -H2O extract 40 min before a 50 g-OGTT' with finger-prick blood samples at -40-, 0-, 15-, 30-, 45-, 60-, 90-, 120-min. In the dose-finding study, 12 healthy subjects (sex: 9M,3F, age: 29 +/- 3 y, BMI: 22.5 +/- 1 kg/m(2)) received 0 g (placebo), 2 g, 4 g, and 6 g of the most efficacious root fraction following the same protocol. Ginsenosides were analyzed using HPLC-UV. Results: In the preparation-finding study, a wide variation in the ginsenoside profiles was achieved across the 3 KRG fractions. This variation coincided with differential effects. The main effects of KRG-rootlets (p = 0.050) and time (p < 0.001) and their interaction (p < 0.1) were significant. This was reflected in a 29% reduction in area under the curve (AUC) by KRG-rootlets compared with placebo (p = 0.052). Conversely, neither KRG-H2O extract nor KRG-body affected glycemia. Stepwise-multiple regression models identified Rg1 as the sole predictor of mean- and AUC postprandial blood glucose. In the dose-finding study, KRG-rootlets were tested as the most efficacious fraction. A significant effect of KRG-rootlets treatment (mean of 3 doses) but not dose was found. The mean of 3 doses decreased AUC by 17% compared with placebo (p = 0.057). Conclusions: Together the studies indicate 2 g KRG-rootlets is sufficient to achieve reproducible reductions in postprandial glycemia. But the longterm sustainability of KRG selected using this approach remains to be tested. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD | - |
dc.title | Korean red ginseng rootlets decrease acute postprandial glycemia: Results from sequential preparation- and dose-finding studies | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1080/07315724.2006.10719519 | - |
dc.identifier.scopusid | 2-s2.0-33747185895 | - |
dc.identifier.wosid | 000236742200002 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, v.25, no.2, pp 100 - 107 | - |
dc.citation.title | JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION | - |
dc.citation.volume | 25 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 100 | - |
dc.citation.endPage | 107 | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | PANAX-QUINQUEFOLIUS-L. | - |
dc.subject.keywordPlus | AMERICAN GINSENG | - |
dc.subject.keywordPlus | HYPOGLYCEMIC ACTIVITY | - |
dc.subject.keywordPlus | ANTIDIABETES DRUGS | - |
dc.subject.keywordPlus | BERRY EXTRACT | - |
dc.subject.keywordPlus | BLOOD-GLUCOSE | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | ESCALATION | - |
dc.subject.keywordPlus | TIME | - |
dc.subject.keywordPlus | GINSENOSIDE-RB2 | - |
dc.subject.keywordAuthor | complementary and alternative medicine | - |
dc.subject.keywordAuthor | ginseng | - |
dc.subject.keywordAuthor | ginsenosides | - |
dc.subject.keywordAuthor | postprandial glycemia | - |
dc.subject.keywordAuthor | OGTT | - |
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