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덱스트로메트르판이 마우스의 일차 체액성 면역반응에 미치는 영향Effects of Dextromethorphan on the Primary Humoral Immune Response in Mice
- Other Titles
- Effects of Dextromethorphan on the Primary Humoral Immune Response in Mice
- Authors
- 표명윤
- Issue Date
- Dec-2006
- Publisher
- 환경독성보건학회
- Keywords
- dextromethorphan; OVA-specific IgM; splenocytes proliferation─ 349 ─※To whom correspondence should be addressed.Tel: +82-2-710-9573; E-mail: mypyo@sookmyung.ac.krphan으로 대사되고 신장으로 배설되는데; 이 대 사물 또한 진해작용을 나타내고 있다(Constanzer etal.; 2005).DXM이 치료용량(60~ 1; dextromethorphan; OVA-specific IgM; splenocytes proliferation─ 349 ─※To whom correspondence should be addressed.Tel: +82-2-710-9573; E-mail: mypyo@sookmyung.ac.krphan으로 대사되고 신장으로 배설되는데; 이 대 사물 또한 진해작용을 나타내고 있다(Constanzer etal.; 2005).DXM이 치료용량(60~ 1
- Citation
- 환경독성보건학회지, v.21, no.4, pp 349 - 355
- Pages
- 7
- Journal Title
- 환경독성보건학회지
- Volume
- 21
- Number
- 4
- Start Page
- 349
- End Page
- 355
- ISSN
- 2093-6400
- Abstract
- Dextromethorphan hydrobromide (DXM) has been widely used as a nonopioid antitussive drug with lowtoxicity and low potential for drug dependency. DXM is a psychotropic drug since 2003 in our country. Thisto DXM dissolved in saline as concentration of 30, 60, and 120 mg/kg b.w. before (day-2) or after (day+ 2)immunization (OVA-antigen, day 0). Thereafter, we measured the increased rate of body weight, relativeweight of organ(thymus, spleen, liver, kidney) and OVA-cytes were exposed to various concentration of DXM(0.001~ 100M) and cultured with B cell mitogen(LPS)and splenocytes proliferations (SP) were measured by MTT-assay. Thymus-weight were slightly changed onday 9 after administration of DXM, but body-, spleen-, liver-, and kidney-control group and DXM-treated group. SP to LPS were significantly decreased at high concentration(100M)when compared with controls. When DXM was administered before or after immunization with OVA-antigen,OVA-specific IgM levels were significantly lowered in a dose-dependent manner. These results indicate thatDXM may depress the primary humoral immune response to the initial antigenic challenge.
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