Rolipram, a phosphodiesterase 4 inhibitor, stimulates inducible cAMP early repressor expression in osteoblasts
- Authors
- Cho, ES; Yu, JH; Kim, MS; Yim, M
- Issue Date
- Feb-2005
- Publisher
- YONSEI UNIV COLL MEDICINE
- Keywords
- osteoblast; cyclic AMP; PDE4 inhibitor; ICER
- Citation
- YONSEI MEDICAL JOURNAL, v.46, no.1, pp 149 - 154
- Pages
- 6
- Journal Title
- YONSEI MEDICAL JOURNAL
- Volume
- 46
- Number
- 1
- Start Page
- 149
- End Page
- 154
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15534
- DOI
- 10.3349/ymj.2005.46.1.149
- ISSN
- 0513-5796
1976-2437
- Abstract
- Phosphodiesterase (PDE) 4 inhibitors have been shown to induce the cAMP-mediated signaling pathway by inhibiting cAMP hydrolysis. This study investigated the effect of a PDE4 inhibitor on the expression of the inducible cAMP early repressor (ICER), which is an endogenous inhibitor of CRE-mediated transcription, in osteoblastic cells. RT-PCR analysis revealed that rolipram, a PDE4 inhibitor, stimulates the ICER mRNA in a dose dependent manner. The induction of ICER mRNA expression by rolipram was suppressed by the inhibitors of protein kinase A (PKA) and p38 MAPK, suggesting the involvement of PKA and p38 MAPK activation in ICER expression by rolipram. It was previously shown that rolipram induced the expression of TNF-related activation-induced cytokine (TRANCE, also known as RANKL, ODF, or OPGL) in osteoblasts. This paper provides evidences that a transcriptional repressor like ICER might modulate TRANCE mRNA expression by rolipram in osteoblasts.
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