Antiinflammatory effects of genipin, an active principle of gardenia
- Authors
- Koo, HJ; 송윤선; Kim, HJ; Lee, YH; Hong, SM; Kim, SJ; Kim, BC; Jin, C; Lim, CJ; Park, EH
- Issue Date
- Jul-2004
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- angiogenesis; antiinflammatory; genipin; inducible nitric oxide synthase; lipid peroxidation; NO (Nitric oxide)
- Citation
- EUROPEAN JOURNAL OF PHARMACOLOGY, v.495, no.2-3, pp 201 - 208
- Pages
- 8
- Journal Title
- EUROPEAN JOURNAL OF PHARMACOLOGY
- Volume
- 495
- Number
- 2-3
- Start Page
- 201
- End Page
- 208
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15853
- DOI
- 10.1016/j.ejphar.2004.05.031
- ISSN
- 0014-2999
1879-0712
- Abstract
- Genipin, the aglycone of geniposide, is metabolically produced from the geniposide in body tissues. The purpose of this study is to clarify some pharmacological actions of genipin. Genipin showed concentration-dependent inhibition on lipid peroxidation induced by Fe++/ ascorbate in rat brain homogenate. Genipin exhibited significant topical antiinflammatory effect shown as an inhibition of croton oil-induced ear edema in mice. Nitric oxide (NO) synthesis by inducible nitric oxide synthase (NOS) is increased in inflammatory diseases and leads to cellular injury. Genipin concentration-dependently (50-300 muM) inhibited NO production and NOS expression upon stimulation by lipopolysaccharide/interferon-gamma (IFN-gamma) in RAW 264.7, a murine macrophage cell line. Genipin markedly blocked lipopolysaccharide-evoked degradation of inhibitor-kappaB-beta (IkappaB-beta), indicating that it exhibits inhibitory effect on NO production through the inhibition of nuclear factor-kappaB (NF-kappaB) activation. It was also shown to contain potent antiangiogenic activity in a dose-dependent manner, which was detected by chick embryo chorioallantoic membrane assay. In summary, we demonstrate that genipin possesses antiinflammatory and is a specific hydroxyl radical scavenger. Its antiangiogenic and NO production-inhibitory properties are also presented. (C) 2004 Elsevier B.V. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 약학대학 > 약학부 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.