Tetrazolo[1,5-a]quinoline as a potential promising new scaffold for the synthesis of novel anti-inflammatory and antibacterial agents
- Authors
- Bekhit, AA; El-Sayed, AA; Aboulmagd, E; Park, JY
- Issue Date
- Mar-2004
- Publisher
- ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
- Keywords
- tetrazolo[ 1.5-a]quinoline; pyrimidyl; anti-inflammatory; antimicrobial; ulcerogenic; acute toxicity
- Citation
- EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.39, no.3, pp 249 - 255
- Pages
- 7
- Journal Title
- EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Volume
- 39
- Number
- 3
- Start Page
- 249
- End Page
- 255
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15902
- DOI
- 10.1016/j.ejmech.2003.12.005
- ISSN
- 0223-5234
1768-3254
- Abstract
- Three series of tetrazolo[ 1,5-alpha]quinoline derivatives have been synthesized. The first series was synthesized starting by the condensation of tetrazolo[1,5-alpha]quinoline-4-carboxaldehyde 2 with substituted thiosemicarbazides, followed by cyclization of the resulting thiosemicarba-zones 3 with malonic acid in the presence of acetyl chloride to give pyrimidyl derivatives 4a-c. The second series was prepared by the condensation of the latter compounds 4a-c with the selected aromatic aldehydes to afford the arylidene derivatives 5a-f. The third series 7a-c was synthesized by condensation of tetrazolo[1,5-a]quinoline-4-carboxaldehyde 2 with the appropriate acetophenone, followed by cyclocon-densation of the formed alpha,beta-unsaturated ketones with thiourea. The newly synthesized compounds were evaluated for their anti-inflammatory and antimicrobial activities. Four compounds were proved to be as active as indomethacin in animal models of inflammation. (C) 2003 Elsevier SAS. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 약학대학 > 약학부 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.