폴리페놀의 비타민 C 안정성 유지와 피부 침투성 증가에 관한 연구Enhancement of the Stability and Skin Penetration of Vitamin C by Polyphenol.
- Other Titles
- Enhancement of the Stability and Skin Penetration of Vitamin C by Polyphenol.
- Authors
- 강재승; 조대호; 이왕재
- Issue Date
- Dec-2004
- Publisher
- 대한면역학회
- Keywords
- Vitamin C; polyphenol; histamine; atopic dermatitis; Vitamin C; polyphenol; histamine; atopic dermatitis
- Citation
- Immune Network, v.4, no.4, pp 250 - 254
- Pages
- 5
- Journal Title
- Immune Network
- Volume
- 4
- Number
- 4
- Start Page
- 250
- End Page
- 254
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15921
- ISSN
- 1598-2629
2092-6685
- Abstract
- Background: It is necessary for human beings to uptake vitamin C through diet or supplements. It is also well-known that vitamin C plays an important role in the prevention of scurvy, enhancement of collagen synthesis and anti-tumor immune response. In addition, there are several recent reports regarding the effective role of vitamin C on the regulation of allergic responses, such as atopic dermatitis and asthma. However, the effective therapeutic and preventive measures using vitamin C are not established yet, since vitamin C is seriously unstable in aqueous solution. Therefore, we have investigated the best way to maintain the stability of vitamin C. Methods: After we making a mixture of polyphenol (0.001, 0.01, 0.1%) and vitamin C (1 mM), the mixtures were placed at room temperature both with/without light protection. And then the concentration of ascorbic acid was measured with HPLC. To analyze the in vivo effect of vitamin C on the regulation of skin allergic reaction, polyphenol (0.1%)-vitamin C (1 mM) mixture was applied to the skin and the production of histamine from mast cell was analyzed by Evans blue dye staining. Results: We have found that the polyphenol has preventive power of oxidation of vitamin C. In addition, the production of histamine was suppressed by the polyphenol (0.1%)-vitamin C (1 mM) mixture. Conclusion: We have reached the conclusion that our study suggests the research guideline for the therapy of atopic dermatitis through vitamin C. (Immune Network 2004;4(4): 250-254)
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