Effects of Cinnamon (<i>Cinnamomum zeylanicum</i>) Extract on Adipocyte Differentiation in 3T3-L1 Cells and Lipid Accumulation in Mice Fed a High-Fat Diet
DC Field | Value | Language |
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dc.contributor.author | Oh, Joohee | - |
dc.contributor.author | Ahn, Song Hee | - |
dc.contributor.author | Zhou, Xiangqin | - |
dc.contributor.author | Lim, Yu Jin | - |
dc.contributor.author | Hong, Sookyeong | - |
dc.contributor.author | Kim, Hyun-Sook | - |
dc.date.accessioned | 2024-01-29T07:30:22Z | - |
dc.date.available | 2024-01-29T07:30:22Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/159605 | - |
dc.description.abstract | Flavonoids and phenolic acid are two of the rich polyphenols found in cinnamon (Cinnamomum zeylanicum). The effects of cinnamon extract on the inhibition of adipocyte differentiation in 3T3-L1 fibroblast cells and prohibitory lipid accumulation in male mice fed a high-fat diet were examined. Upon treating 3T3-L1 cells with cinnamon for 3 days, the cinnamon inhibited lipid accumulation and increased gene expression levels, such as those of adiponectin and leptin. In in vivo experiments, mice were randomized into four groups after a one-week acclimation period, as follows: normal diet, normal diet + 1% cinnamon extract, high-fat diet, and high-fat diet + 1% cinnamon extract. After 14 weeks of supplementation, we found that cinnamon extract increased the expression of lipolysis-related proteins, such as AMPK, p-ACC, and CPT-1, and reduced the expression of lipid-synthesis-related proteins, such as SREBP-1c and FAS, in liver tissue. Our results show that cinnamon extract may exhibit anti-obesity effects via the inhibition of lipid synthesis and adipogenesis and the induction of lipolysis in both 3T3-L1 fibroblast cells and mice fed a high-fat diet. Accordingly, cinnamon extract may have potential anti-obesity effects. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Effects of Cinnamon (<i>Cinnamomum zeylanicum</i>) Extract on Adipocyte Differentiation in 3T3-L1 Cells and Lipid Accumulation in Mice Fed a High-Fat Diet | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/nu15245110 | - |
dc.identifier.scopusid | 2-s2.0-85180677820 | - |
dc.identifier.wosid | 001132510400001 | - |
dc.identifier.bibliographicCitation | NUTRIENTS, v.15, no.24 | - |
dc.citation.title | NUTRIENTS | - |
dc.citation.volume | 15 | - |
dc.citation.number | 24 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | ACID OXIDATION | - |
dc.subject.keywordPlus | CEYLON CINNAMON | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | AMPK | - |
dc.subject.keywordPlus | ADIPONECTIN | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | LEPTIN | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | metabolic syndrome | - |
dc.subject.keywordAuthor | cinnamon | - |
dc.subject.keywordAuthor | anti-obesity | - |
dc.subject.keywordAuthor | adipocytes | - |
dc.subject.keywordAuthor | lipolysis | - |
dc.subject.keywordAuthor | AMP-activated kinase (AMPK) | - |
dc.identifier.url | https://www.mdpi.com/2072-6643/15/24/5110 | - |
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