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Synthesis and antiviral activity of novel C-methyl branched cyclopropyl nucleosides

Authors
Kwak, EYHong, JHPark, YChoi, BG
Issue Date
Sep-2003
Publisher
PHARMACEUTICAL SOCIETY KOREA
Keywords
cyclopropyl nucleoside; antiviral agent; Simmons-Smith cyclopropanation
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.26, no.9, pp.679 - 685
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
Volume
26
Number
9
Start Page
679
End Page
685
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16170
DOI
10.1007/BF02976674
ISSN
0253-6269
Abstract
A series of novel cyclopropyl nucleosides was synthesized using the highly stereoselective Simmons-Smith reaction starting from 1,2:5,6-di-O-isopropylidene-D-mannitol. The structural assignments of these nucleosides were determined by NMR studies and X-ray crystallography. All the synthesized nucleosides were assayed against several viruses.
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